Compare and contrast actin filaments and microtubules.

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Compare and contrast actin filaments and microtubules.

Many reviews have been written on the biochemistry and cell biology of actin filaments and microtubules individually (see Korn, 1982; Kirschner and Mitchison, 1986; Pollard, 1986a; Pollard and Cooper, 1986; Gelfand and Bershadsky, 1991; Caplow, 1992). Most labs work on one polymer or the other, which has led to something of a gulf between the actin and microtubule research fields. As a broad (a...

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Organelle Movements along Actin Filaments and Microtubules.

Organelle movements involving microtubules and actin filaments are a conspicuous and important feature of many plant cells. Movements have recently been supported in preparations of demembranated cytoplasm and reconstituted from purified proteins. The favored mechanism involves organelles carrying a force-generating ATPase moving along a track provided by either actin filaments or microtubules....

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Interaction of actin filaments with microtubules

Several cytological observations support the idea that actin filaments interact with microtubules, but the strongest evidence comes from biochemical experiments. The cytological observations include the colocalization of microtubules and actin in the mitotic spindle of dividing cells by electron microscopy (1-3) and light microscopy with fluorescent probes for actin (4-6) . There is, however, d...

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Axon branching requires interactions between dynamic microtubules and actin filaments.

Cortical neurons innervate many of their targets by collateral axon branching, which requires local reorganization of the cytoskeleton. We coinjected cortical neurons with fluorescently labeled tubulin and phalloidin and used fluorescence time-lapse imaging to analyze interactions between microtubules and actin filaments (F-actin) in cortical growth cones and axons undergoing branching. In grow...

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Microtubules and actin filaments: dynamic targets for cancer chemotherapy.

Microtubules and actin filaments play important roles in mitosis, cell signaling, and motility. Thus these cytoskeletal filaments are the targets of a growing number of anti-cancer drugs. In this review we summarize the current understanding of the mechanisms of these drugs in relation to microtubule and actin filament polymerization and dynamics. In addition, we outline how, by targeting micro...

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ژورنال

عنوان ژورنال: Molecular Biology of the Cell

سال: 1992

ISSN: 1059-1524,1939-4586

DOI: 10.1091/mbc.3.12.1309